New peptide catalyst enables stereoselective head-to-tail macrocycle synthesis

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Mar 4, 2026 - 21:34

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New peptide catalyst enables stereoselective head-to-tail macrocycle synthesis

A team at ETH Zurich developed a new peptide-based organocatalyst that handles macrocycle formation from start to finish. Macrocyclic compounds are ubiquitous both in nature and in the chemical industrial setup. They are ring-shaped molecules with 12 or more atoms and are key components of many natural products and pharmaceuticals. Their unique structures let them lock onto specific proteins with impressive precision, making them exciting candidates for new therapies. Some even come with fun names—like robotnikinin, a macrocycle that inhibits the Sonic Hedgehog (Shh) protein. However, synthesizing them hasn't been as fun as their names—until now.